This study was carried out to morphologically investigate the patogenesis of chronic bacterial pros-tatitis. ,Male Sprague-Dawley rats were inoculated 0.2m of Escherichia coli(10cells/ml) into the prostate and sacrificed 1, 2, 3, and 5 weeks after inoculation. Ten animals in each group were ob-served by light and electron micrscopy. In addition, immunocytochemisiry for IgG, IgA, and Ig~VI in the prostate was performed.
On fight microscopy, acute purulent inflammation occurred in the prostate with necrosis and . sloughing of epithelial cells and severe infiltration of neutrophils and macrophages in the interstitium. Acute inflammation was persisted until 2 weE~ks after inoculation. In 3 weeks after inoculation atrophy and loss of prostatic acini and fibrosis of interstitium, which were signs of chronic prostatitis, appeared. Immunoglobulin IgG, IgA, and lg~I were: strongly positive in inflammatory cells and interstitium during the period of experiments.
On electron microscopy, there were marked exudation of neutrophils and necrotic cells in the acini ~with focal necrosis of lining epithelium. Infiltration of neutrophils, and macrophages, deposition of fihrins, and marked congestion appeared in the interstitium at 1 week after inoculation of E. coll. These findings persisted for many weeks. There were membrane bound rod bodies in the lysosomes and cytoplasm of the epithelium.
According to above results it is suggested that chronic ha~terial prostatitis in this model was also-dated with persistent immunological reaction on the prostate resulting in chronic inflammation of the prostate.
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